TABLE OF CONTENTS:
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STUDY 1 IN VITRO
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STUDY 2 IN VIVO
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STUDY 1 IN VITRO
Purpose of Study:
Demonstrate ability of the Hand Sanitzer Lotion with Invisicare to adhere to skin under conditions that simulate normal working conditions. Reveal the Hand Sanitzer Lotion with Invisicare ability to persist on skin throughout multiple hand washes and exposure to detergents, chemicals and solvents.
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Testing Laboratory:
APPLIED CONSUMER SERVICES, INC. (ACS)
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Protocol:
The Hand Sanitzer Lotion with Invisicare was applied to fritted glass membranes to simulate a normal application on skin. The membranes were subjected to an agitated 5% Ammonium Hydroxide wash with tests being conducted over six hours. Gravimetric analysis was used to determine the level of adherence to the glass membranes. An additional test with artificial perspiration yielded no change in persistence.
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Results:
- 82% remained bonded to membrane after 3 hours.
- 68% remained bonded to membrane after 6 hours.
Note: Additional clinical studies measuring Trans-epidermal Water Loss (TEWL) and Corneometer measurements show that the Hand Sanitzer Lotion with Invisicare exhibits selective impermeability required to allow for normal respiration and prevent hazardous environmental challenge.
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STUDY 2 IN VIVO
Purpose of Study:
Reveal the Hand Sanitzer Lotion with Invisicare ability to persist on skin throughout multiple hand washes and exposure to detergents, chemicals and solvents.
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Testing Laboratory:
CALIFORNIA SKIN RESEARCH INSTITUTE (CSRI)
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Protocol:
Utilizing 30 ethnically diverse human subjects, the Hand Sanitzer Lotion with Invisicare was applied to the volar forearm, and then scrubbed with gauze saturated with 5% Ammonium Hydroxide at intervals of 10 minutes, 2 hours and 4 hours. The same gravimetric analysis as used in the in vitro studies, were performed on the skin wash solutions. Throughout the four-hour test period, punch biopsies were harvested from random subjects for examination under Electron Microscopy and Atomic Force Microscopy.
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Results:
- The Hand Sanitzer Lotion with Invisicare bound to skin greater than to fritted glass membrane.
- Human perspiration studies replicated the results from In Vitro study.
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No Hand Sanitzer Lotion with Invisicare
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10 minutes post application with the Hand Sanitzer Lotion with Invisicare firmly bound to Stratum Corneum.
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2 hours post application the Hand Sanitzer Lotion with Invisicare firmly bound to Stratum Corneum.
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4 hours post application the Hand Sanitzer Lotion with Invisicaree firmly bound to Stratum Corneum.
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Note: This document is an excerpt taken from Chapter 4 of the "Report of The Scientific Advisory Committee on The Skinvisible® Line of Products".
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