TABLE OF CONTENTS:
Purpose of Study:
Demonstrate ability of the Hand Sanitzer Lotion with Invisicare to act as an effective barrier to noxious agents.
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Testing Laboratory:
APPLIED CONSUMER SERVICES, INC. (ACS)
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Protocol:
An impermeability study was conducted under in vitro laboratory conditions using a gravimetric method to determine levels of challenge liquid passing through diffusion chambers separated by a fritted glass membrane coated with an Invisicare formulation.
In the first study, twenty-eight (28) different toxic agents representative of a chemically diverse group of solvents, acids, bases, dyes, insecticides, herbicides and hydrocarbons were tested for their ability to permeate the Hand Sanitzer Lotion with Invisicare.
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Results:
- In all cases the Hand Sanitzer Lotion with Invisicare resisted permeation by all tested substances.
- In all cases permeability exclusion exceeded 99% except for the following:
- 100% gasoline (96.7 % / 96.6%)
- Methylene Chloride (28.6% / 31.8 % )
Note: Additional clinical studies measuring Trans-epidermal Water Loss (TEWL) and Corneometer measurements show that Invisicare exhibits selective impermeability required to allow for normal respiration and prevent hazardous environmental challenge.
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Table 1: Summary of findings from Challenge Liquid Impermeability Test
|
Test No.
|
Chamber A Challenge Liquid
|
Receiving Chamber (H2O) 3 Hr / 6 Hr Conc.
|
Percent Retained in Original Chamber
|
|
1
|
16% Acetone
|
0.18 % / 0.47 %
|
99.9 % / 97.1 %
|
|
2
|
10 % Formaldehyde
|
0.04 % / 0.07 %
|
99.6 % / 99.3 %
|
|
3
|
5 % Ammonia
|
0.02 % / 0.04 %
|
99.6 % / 99.2 %
|
|
4
|
5 % nAc1O (Clorox)
|
0.09 % / 0.12 %
|
98.2 % / 97.6 %
|
|
5
|
3 % Hydrogen Peroxide
|
0.036 % /0.060%
|
98.8 % / 98.0 %
|
|
6
|
10 % Conc. HC1 (38)
|
0.005 % / 0.009 %
|
99.9% / 99.8 %
|
|
7
|
10 % Sodium Hydroxide
|
0.04 % / 0.07 %
|
99.6 % / 99.3 %
|
|
8
|
1 % Baygon
|
0.005 % / 0.007 %
|
99.5 % / 99.3 %
|
|
9
|
1 % Malathion
|
<0.01% / <0.01%
|
>99% / >99%
|
|
10
|
1 % Dursban/ Chlorpyrifos
|
<0.01% / <0.01%
|
>99% / >99%
|
|
11
|
1 % Diazinon
|
<0.01% / <0.01%
|
>99% / >99%
|
|
12
|
1 %Atrazine
|
<0.01% / <0.01%
|
>99% / >99%
|
|
13
|
100 % Perchloroethylene
|
0.670 % / 0.673 %
|
99.33 % / 99.33 %
|
|
14
|
100% Methylene Chloride
|
28.6% / 31.8 % by vol.
|
71.4 % / 68.2 %**
|
|
15
|
100 % Gasoline
|
3.3 % / 3.4% PPM
|
96.7 % / 96.6 %
|
|
16
|
100 % Diesel Fuel
|
2.1 /2.1 PPM
|
99.99 % / 99.99 %
|
|
17
|
100 % Paint Thinner
|
<1 / 27 PPM
|
99.99 % / 99.99 %
|
|
18
|
100 % Paint Stripper
|
7.7 / 37.0 PPM
|
99.99 % / 99.99 %
|
|
19
|
6 % Latex With Protein
|
<0.005 % (4hrs)
|
> 99.92 %
|
|
20
|
1 % D & C Red 33
|
9.8 / 20.9 PPM
|
99.90 % / 99.71%
|
|
21
|
1 % D & C Green 28
|
<10 / <10 PPM
|
>99.90 % / >99.90 %
|
|
22
|
1 % D & C Green 6
|
0.037 / 2.53 PPM
|
99.99 % / 99.97 %
|
|
23
|
1 % D & C Yellow 5
|
18.4 / 45.9 PPM
|
99.82 % / 99.64 %
|
|
24
|
1 % D & C Red 4
|
1.86 / 14.8 PPM
|
99.88 % / 99.85 %
|
|
25
|
1 % D & C Red 40
|
0.019 / 8.50 PPM
|
99.99 % / 99.91 %
|
|
26
|
1 % D & C Blue 1
|
2.98 / 10.48 PPM
|
99.97 % / 99.90 %
|
|
27
|
1 % D & C Red 3
|
14.8 / 22.68 PPM
|
99.85 % / 99.77 %
|
|
28
|
100 % Wax Stripper
|
84.7 / 226 PPM
|
99.99 % / 99.98 %
|
Note: This document is an excerpt taken from Chapter 4 of the "Report of The Scientific Advisory Committee on The Skinvisible® Line of Products".
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